One professor of literature renounces his fight to discriminate wrong from right readings. He succumbs to pressures from theorists and practitioners in the profession at large and enters a world of unimagined intellectual freedom. After all, to suggest that some readings might be wrong is not only to engage in intellectual discrimination, but to enter into complicity with a number of imperious gestures that carry dire political consequences. Coming to terms with his newfound freedom to embrace all interpretations of texts (...) as equally valid, he outlines for those who follow thirteen rules that guide hermeneutical practice in our postmodern age. (shrink)

The history of the Euclidean Steiner tree problem, which is the problem of constructing a shortest possible network interconnecting a set of given points in the Euclidean plane, goes back to Gergonne in the early nineteenth century. We present a detailed account of the mathematical contributions of some of the earliest papers on the Euclidean Steiner tree problem. Furthermore, we link these initial contributions with results from the recent literature on the problem.

Over the past 50 years, academic-industrial collaborations and technology transfer have played an increasingly prominent role in the biomedical sciences. These relationships can speed the delivery of innovative drugs and medical technologies to clinical practice, creating important public health benefits as well as income for universities and their faculty. At the same time, they raise ethical concerns, particularly when research involves human subjects in clinical trials. Lapses in oversight of industry sponsored clinical trials at universities, and especially patient deaths in (...) a number of trials, have brought these issues into the public spotlight and have led the federal government to intensify its oversight of clinical research. The leadership of Harvard Medical School convened a group of leaders in academic medicine to formulate guidelines on individual financial conflicts of interest. They and other groups are working to formulate a national consensus on this issue. (shrink)

Martin argues that literary studies remain mired in the anomalies of a linguistic methodology derived from early 20th-century language philosophy, a view challenged not only by theoretical physics, but also by compelling advances in philosophic semantics.

The paper is an attempt to set the social and historical background against which the Royal Institution was founded, and to trace the events in its very early history. The founder of the Institution was Benjamin Thompson, Count Rumford, that soldier of fortune who took service with the Elector Palatine of Bavaria, and it was in the course of his duties in Munich that his interest in the practical problems of philanthropy was aroused.In London, in the concluding years of the (...) eighteenth century, he was drawn into the group of philanthropists and reformers among whom William Wilberforce was the leading figure, and Sir Thomas Bernard, Treasurer of the Foundling Hospital, one of the most active members. The focus of their activities was the Society for Bettering the Condition and Increasing the Comforts of the Poor, and to this Society Rumford submitted his proposals for a new scientific institution in London, designed to improve the lot of the poor and the working classes by the application of science to useful purposes.It was decided to make an appeal for funds, Rumford's proposals were circulated, and the Count succeeded in interesting the President of the Royal Society, Sir Joseph Banks, who took the Chair at the early meetings and allowed them to be held at his house, 32 Soho Square. At a meeting held there on 7 March 1799, the new institution was formed by resolution of the subscribers of 50 guineas each, who became the first Proprietors of the Royal Institution of Great Britain, as it was afterwards named in its Royal Charter. (shrink)

The paper covers a period of little more than two years in the early history of the Royal Institution, but it is the period in which the house in Albemarle Street was purchased and Count Rumford devoted all his energies to establishing in it the Institution he had conceived. The house was enlarged and adapted to its new purpose; at first a temporary and later the well-known lecture theatre were built. The first Resident Professor and lecturer in the new theatre (...) was Thomas Garnett, whose brief and unhappy connection with the Royal Institution is recorded. (shrink)

Calling post-modernism merely "the last tortured gasps of the old paradigm, not the birth-cries of the new," Martin (affiliations, academic or otherwise, not noted) seeks to move along to a "post-Western" perspective on history. He writes from a Green viewpoint (anarchist, feminist, and ecological), giving much credit to American anarchist Murray Bookchin, who he calls the last great Western philosopher. Double-spaced. Annotation copyrighted by Book News Inc., Portland, OR.

Greening the Past argues that 'western civilization' is rapidly approaching a crisis unique in world history, and that a new world-view now emerging is best encapsulated by a Green, anarchist-ecological analysis. The approach outlined in this book embraces general systems theory and recent discoveries in physics as well as key philosophical issues such as the nature of time, objectivity and causality, and an eco-psychological view of human nature. It includes new interpretations of the place of myth and language in historical (...) writing and urges a re-evaluation of the dialectical method. (shrink)

Oppression and the Human Condition is both a valuable teaching tool and an insightful addition to scholarship on the philosophy of Jean-Paul Sartre. Students and teachers will find it an excellent and accessible introduction to Sartre's existentialism, ideal for courses in existentialist and 20th century philosophy. Equally, Sartre scholars will find that the book, especially the sections on oppression and "bad faith," gives them much to think about. Author Thomas Martin applies Sartre's philosophy to contemporary issues and concerns, (...) and draws on two case studies to make his point. The cases examine modern-day oppressors--in one case an anti-semite, in the other a sexist who objectifies women--in the context of Sartre's "bad faith." The case studies also reinforce Martin's argument that Sartre's early philosophy, especially his concept of "bad faith," provides a framework for discussions of oppressions such as racism and sexism. (shrink)

While artists often present their works as communicating to and through them, this idea has rarely been taken seriously, nor empirically studied from a communicational perspective. Building upon the pragmatist tradition, we show how this particular form of communication takes place. Using Peirce’s concept of abduction, we argue that a creative process essentially happens when a resonance between two materials leads to the unification of these materials into a new whole. Drawing upon a case study, we show how we can (...) retrace such resonances by paying close attention to the interactions between participants collectively involved in a creative project. This paper makes an important contribution to communication studies by revealing the communicational mechanism of our creative impulsions. It also opens new avenues for the study of artistic endeavors as well as other creative activities such as science, politics, or design. (shrink)

Multigene delivery and expression systems are emerging as key technologies for many applications in contemporary biology. We have developed new methods for multigene delivery and expression in eukaryotic hosts for a variety of applications, including production of protein complexes for structural biology and drug development, provision of multicomponent protein biologics, and cell‐based assays. We implemented tandem recombineering to facilitate rapid generation of multicomponent gene expression constructs for efficient transformation of mammalian cells, resulting in homogenous cell populations. Analysis of multiple parameters (...) in living cells may require co‐expression of fluorescently tagged sensors simultaneously in a single cell, at defined and ideally controlled ratios. Our method enables such applications by overcoming currently limiting challenges.Here, we review recent multigene delivery and expression strategies and their exploitation in mammalian cells. We discuss applications in drug discovery assays, interaction studies, and biologics production, which may benefit in the future from our novel approach. (shrink)

Controversy and activism have long been linked to the subject of primate research. Even in the midst of raging ethical debates surrounding fertility treatments, genetically modified foods and stem-cell research, there has been no reduction in the campaigns of activists worldwide. Plying their trade of intimidation aimed at ending biomedical experimentation in all animals, they have succeeded in creating an environment where research institutions, often painted as guilty until proven innocent, have avoided addressing the issue for fear of becoming targets. (...) One area of intense debate is the use of primates in stroke research. Despite the fact that stroke kills more people each year than AIDS and malaria, and less than 5% of patients are candidates for current therapies, there is significant opposition to primate stroke research. A balanced examination of the ethics of primate stroke research is thus of broad interest to all areas of biomedical research. (shrink)

The study of anarchism as a philosophical, political, and social movement has burgeoned both in the academy and in the global activist community in recent years. Taking advantage of this boom in anarchist scholarship, Nathan J. Jun and Shane Wahl have compiled twenty-six cutting-edge essays on this timely topic in New Perspectives on Anarchism.

Context Opioid treatment agreements (OTAs) are documents that clinicians present to patients when prescribing opioids that describe the risks of opioids and specify requirements that patients must meet to receive their medication. Notwithstanding a lack of evidence that OTAs effectively mitigate opioids’ risks, professional organizations recommend that they be implemented, and jurisdictions increasingly require them. We sought to identify the jurisdictions that require OTAs, how OTAs might affect the outcomes of lawsuits that arise when things go wrong, and instances in (...) which the law permits flexibility for clinicians and health care institutions to adopt best practices. -/- Methods We surveyed the laws and regulations of all 50 states and the District of Columbia to identify which jurisdictions require the use of OTAs, the circumstances in which OTA use is mandatory, and the terms OTAs must include (if any). We also surveyed criminal and civil judicial decisions in which OTAs were discussed as evidence on which a court relied to make its decision to determine how OTA use influences litigation outcomes. -/- Findings Results show that a slight majority (27) of jurisdictions now require OTAs. With one exception, the jurisdictions’ requirements for OTA use are triggered at least in part by long-term prescribing. There is otherwise substantial variation and flexibility within OTA requirements. Results also show that even in jurisdictions where OTA use is not required by statute or regulation, OTA use can inform courts’ reasoning in lawsuits involving patients or clinicians. Sometimes, but not always, OTA use legally protects clinicians from liability. -/- Conclusions -/- Our results show that OTA use is entwined with legal obligations in various ways. Clinicians and health care institutions should identify ways for OTAs to enhance clinician–patient relationships and patient care within the bounds of relevant legal requirements and risks. (shrink)

Assessment of decision-making capacity (DMC) can be difficult in acquired brain injury (ABI) particularly with the syndrome of organic personality disorder (OPD) (the “frontal lobe syndrome”). Clinical neuroscience may help but there are challenges translating its constructs to the decision-making abilities considered relevant by law and ethics. An in-depth interview study of DMC in OPD was undertaken. Six patients were purposefully sampled and rich interview data were acquired for scrutiny using interpretative phenomenological analysis. Interview data revealed that awareness of deficit (...) and thinking about psychological states can be present. However, the awareness of deficit may not be “online” and effectively integrated into decision-making. Without this online awareness of deficit the ability to appreciate or use and weigh information in the process of deciding some matters appeared absent. We argue that the decision-making abilities discussed are: (1) necessary for DMC, (2) threatened by ABI, and (3) assessable at interview. Some advice for practically incorporating these abilities within assessments of DMC in patients with OPD is outlined. (shrink)

Thanks to Barton Palmer and John McMillan for these thoughtful commentaries. We found much to agree with and it is striking how so many of the issues relating to decision-making capacity assessment find resonances outside of an English jurisdiction. California and New Zealand are clearly grappling with a very similar set of issues and the commentaries speak to the international nature of these discussions.We will pick up on some main points the commentaries raise.As Palmer notes, DMC law is vulnerable to (...) the criticism that it does not attend to the authenticity of a decision. In ordinary language, this is the idea that someone is deciding while “not their self” or that it is the “illness speaking.” There is a... (shrink)

We report on an interview-based study of decision-making capacity in two classes of patients suffering from depression. Developing a method of second-person hermeneutic phenomenology, we articulate the distinctive combination of temporal agility and temporal inability characteristic of the experience of severely depressed patients. We argue that a cluster of decision-specific temporal abilities is a critical element of decision-making capacity, and we show that loss of these abilities is a risk factor distinguishing severely depressed patients from mildly/moderately depressed patients. We explore (...) the legal and clinical consequences of this result. (shrink)